A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1.

The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms' tumor. In this study, we identified par-4 (for prostate apoptosis response) as a WT1-interacting protein that itself functions as a transcrip...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Johnstone, R W, See, R H, Sells, S F, Wang, J, Muthukkumar, S, Englert, C, Haber, D A, Licht, J D, Sugrue, S P, Roberts, T, Rangnekar, V M, Shi, Y
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231698/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8943350/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.12.6945
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