A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1.

The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms' tumor. In this study, we identified par-4 (for prostate apoptosis response) as a WT1-interacting protein that itself functions as a tran...

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Autores principales: Johnstone, R W, See, R H, Sells, S F, Wang, J, Muthukkumar, S, Englert, C, Haber, D A, Licht, J D, Sugrue, S P, Roberts, T, Rangnekar, V M, Shi, Y
Formato: Artigo
Lenguaje:Inglês
Publicado: 1996
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC231698/
https://ncbi.nlm.nih.gov/pubmed/8943350
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