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Truncated WT1 mutants alter the subnuclear localization of the wild-type protein.

WT1 encodes a zinc-finger protein, expressed as distinct isoforms, that is inactivated in a subset of Wilms tumors. Both constitutional and somatic mutations disrupting the DNA-binding domain of WT1 result in a potentially dominant-negative phenotype. In generating inducible cell lines expressing wi...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Englert, C, Vidal, M, Maheswaran, S, Ge, Y, Ezzell, R M, Isselbacher, K J, Haber, D A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40275/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8618823/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.26.11960
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