Truncated WT1 mutants alter the subnuclear localization of the wild-type protein.

WT1 encodes a zinc-finger protein, expressed as distinct isoforms, that is inactivated in a subset of Wilms tumors. Both constitutional and somatic mutations disrupting the DNA-binding domain of WT1 result in a potentially dominant-negative phenotype. In generating inducible cell lines expressing wi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Englert, C, Vidal, M, Maheswaran, S, Ge, Y, Ezzell, R M, Isselbacher, K J, Haber, D A
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1995
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC40275/
https://ncbi.nlm.nih.gov/pubmed/8618823
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak