Kinetic Mechanistic and Structural Modeling Studies of Truncated Wild-Type LRRK2 and the Mutant G2019S

Leucine-rich repeat kinase 2 (LRRK2), a large and complex protein that possesses two enzymatic properties, kinase and GTPase, is one of the major genetic factors in Parkinson’s disease (PD). Here, we characterize the kinetic and catalytic mechanisms of truncated wild-type LRRK2 (t-wt) and its most c...

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Détails bibliographiques
Auteurs principaux: Liu, Min, Kang, Stephanie, Ray, Soumya, Jackson, Justin, Zaitsev, Alexandra D., Gerber, Scott A., Cuny, Gregory D., Glicksman, Marcie A.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205922/
https://ncbi.nlm.nih.gov/pubmed/21961647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201173d
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