Development of a Mechanism-based HTS Assay for Leucine Rich Repeat Kinase2—Discovery of LRRK2 Inhibitors

LRRK2 is a large and complex protein that possesses kinase and GTPase activities and has emerged as the most relevant player in PD pathogenesis possibly through a toxic gain-of-function mechanism. Kinase activity is a critical component of LRRK2 function and represents a viable target for drug disco...

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Main Authors: Liu, Min, Poulose, Shibu, Schuman, Eli, Zaitsev, Alexandra D., Dobson, Brittany, Auerbach, Ken, Seyb, Kathleen, Cuny, Gregory D., Glicksman, Marcie A., Stein, Ross L., Yue, Zhenyu
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921631/
https://ncbi.nlm.nih.gov/pubmed/20566370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2010.05.033
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