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Kinetic Mechanistic Studies of WT Leucine-Rich Repeat Kinase2: Characterization of the Kinase and GTPase Activities
Recent studies have identified mutations in the leucine-rich repeat kinase2 gene (LRRK2) in the most common familial forms and some sporadic forms of Parkinson’s disease (PD). LRRK2 is a large and complex protein that possesses kinase and GTPase activities. Some LRRK2 mutants enhance kinase activity...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2897705/ https://ncbi.nlm.nih.gov/pubmed/20146535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901851y |
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