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Kinetic Mechanistic Studies of WT Leucine-Rich Repeat Kinase2: Characterization of the Kinase and GTPase Activities

Recent studies have identified mutations in the leucine-rich repeat kinase2 gene (LRRK2) in the most common familial forms and some sporadic forms of Parkinson’s disease (PD). LRRK2 is a large and complex protein that possesses kinase and GTPase activities. Some LRRK2 mutants enhance kinase activity...

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Bibliografiske detaljer
Main Authors: Liu, Min, Dobson, Brittany, Glicksman, Marcie A., Yue, Zhenyu, Stein, Ross L.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897705/
https://ncbi.nlm.nih.gov/pubmed/20146535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901851y
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