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Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson’s disease R1441C/G mutants

Mutations in Leucine-rich repeat kinase 2 (LRRK2) are linked to the most common familial forms and some sporadic forms of Parkinson’s disease (PD). The LRRK2 protein contains two well-known functional domains, MAPKKK-like kinase and Rab-like GTPase domains. Emerging evidence shows that LRRK2 contain...

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Detalhes bibliográficos
Main Authors: Li, Xianting, Tan, Yin-Cai, Poulose, Shibu, Olanow, C. Warren, Huang, Xin-Yun, Yue, Zhenyu
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827244/
https://ncbi.nlm.nih.gov/pubmed/17623048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2007.04743.x
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