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Type II Kinase Inhibitors Show an Unexpected Inhibition Mode against Parkinson’s Disease-Linked LRRK2 Mutant G2019S

A number of well-known type II inhibitors (ATP non-competitive) that bind kinases in their DFG-out conformation were tested against wild-type LRRK2 and the most common Parkinson’s disease-linked mutation G2019S. We found that traditional type II inhibitors exhibit surprising variability in their inh...

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Main Authors: Liu, Min, Bender, Samantha A., Cuny, Gregory D, Sherman, Woody, Glicksman, Marcie, Ray, Soumya S.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966205/
https://ncbi.nlm.nih.gov/pubmed/23379419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3012077
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