Kinetic Mechanistic and Structural Modeling Studies of Truncated Wild-Type LRRK2 and the Mutant G2019S

Leucine-rich repeat kinase 2 (LRRK2), a large and complex protein that possesses two enzymatic properties, kinase and GTPase, is one of the major genetic factors in Parkinson’s disease (PD). Here, we characterize the kinetic and catalytic mechanisms of truncated wild-type LRRK2 (t-wt) and its most c...

Full description

Saved in:
Bibliographic Details
Main Authors: Liu, Min, Kang, Stephanie, Ray, Soumya, Jackson, Justin, Zaitsev, Alexandra D., Gerber, Scott A., Cuny, Gregory D., Glicksman, Marcie A.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205922/
https://ncbi.nlm.nih.gov/pubmed/21961647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201173d
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items