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Kinetic Mechanistic and Structural Modeling Studies of Truncated Wild-Type LRRK2 and the Mutant G2019S
Leucine-rich repeat kinase 2 (LRRK2), a large and complex protein that possesses two enzymatic properties, kinase and GTPase, is one of the major genetic factors in Parkinson’s disease (PD). Here, we characterize the kinetic and catalytic mechanisms of truncated wild-type LRRK2 (t-wt) and its most c...
में बचाया:
| मुख्य लेखकों: | , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2011
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3205922/ https://ncbi.nlm.nih.gov/pubmed/21961647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201173d |
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