Overexpression of wild-type or mutants forms of CEBPA alter normal human hematopoiesis

C/EBPα (CEBPA) is mutated in approximately 8 % of AML in both familial and sporadic AML and, with FLT3 and NPM1, has received most attention as a predictive marker of outcome in patients with normal karyotype disease. Mutations clustering to either the N- or C-terminal (N-and C-ter) portions of the...

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Main Authors: Quintana-Bustamante, Oscar, Smith, S.Lan-Lan, Griessinger, Emmanuel, Reyal, Yasmin, Vargaftig, Jacques, Lister, T. Andrew, Fitzgibbon, Jude, Bonnet, Dominique
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378638/
https://ncbi.nlm.nih.gov/pubmed/22371011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.38
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