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HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed

HSVs transit from vigorous replication at the portal of entry into the body to a latent state in sensory neurons in which only noncoding (e.g., latency-associated transcript) and micro-RNAs are expressed. In productive infection, viral genes must be sequentially derepressed at two checkpoints. A lea...

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Détails bibliographiques
Auteurs principaux: Zhou, Guoying, Du, Te, Roizman, Bernard
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568314/
https://ncbi.nlm.nih.gov/pubmed/23341636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222497110
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