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HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed
HSVs transit from vigorous replication at the portal of entry into the body to a latent state in sensory neurons in which only noncoding (e.g., latency-associated transcript) and micro-RNAs are expressed. In productive infection, viral genes must be sequentially derepressed at two checkpoints. A lea...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3568314/ https://ncbi.nlm.nih.gov/pubmed/23341636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222497110 |
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