FKBP12.6 Activates RyR1: Investigating the Amino Acid Residues Critical for Channel Modulation

We have previously shown that FKBP12 associates with RyR2 in cardiac muscle and that it modulates RyR2 function differently to FKBP12.6. We now investigate how these proteins affect the single-channel behavior of RyR1 derived from rabbit skeletal muscle. Our results show that FKBP12.6 activates and...

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Dades bibliogràfiques
Autors principals: Venturi, Elisa, Galfré, Elena, O’Brien, Fiona, Pitt, Samantha J., Bellamy, Stuart, Sessions, Richard B., Sitsapesan, Rebecca
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2014
Matèries:
Channels and Transporters
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945099/
https://ncbi.nlm.nih.gov/pubmed/24559985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.12.041
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