FKBP12.6 Activates RyR1: Investigating the Amino Acid Residues Critical for Channel Modulation

We have previously shown that FKBP12 associates with RyR2 in cardiac muscle and that it modulates RyR2 function differently to FKBP12.6. We now investigate how these proteins affect the single-channel behavior of RyR1 derived from rabbit skeletal muscle. Our results show that FKBP12.6 activates and...

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Detalhes bibliográficos
Main Authors: Venturi, Elisa, Galfré, Elena, O’Brien, Fiona, Pitt, Samantha J., Bellamy, Stuart, Sessions, Richard B., Sitsapesan, Rebecca
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2014
Assuntos:
Channels and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945099/
https://ncbi.nlm.nih.gov/pubmed/24559985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.12.041
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