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FKBP12 Activates the Cardiac Ryanodine Receptor Ca(2+)-Release Channel and Is Antagonised by FKBP12.6
Changes in FKBP12.6 binding to cardiac ryanodine receptors (RyR2) are implicated in mediating disturbances in Ca(2+)-homeostasis in heart failure but there is controversy over the functional effects of FKBP12.6 on RyR2 channel gating. We have therefore investigated the effects of FKBP12.6 and anothe...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3283708/ https://ncbi.nlm.nih.gov/pubmed/22363773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031956 |
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