FKBP12 Activates the Cardiac Ryanodine Receptor Ca(2+)-Release Channel and Is Antagonised by FKBP12.6

Changes in FKBP12.6 binding to cardiac ryanodine receptors (RyR2) are implicated in mediating disturbances in Ca(2+)-homeostasis in heart failure but there is controversy over the functional effects of FKBP12.6 on RyR2 channel gating. We have therefore investigated the effects of FKBP12.6 and anothe...

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Bibliografiska uppgifter
Huvudupphovsmän: Galfré, Elena, Pitt, Samantha J., Venturi, Elisa, Sitsapesan, Mano, Zaccai, Nathan R., Tsaneva-Atanasova, Krasimira, O'Neill, Stephen, Sitsapesan, Rebecca
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283708/
https://ncbi.nlm.nih.gov/pubmed/22363773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031956
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