TLR7 preconditioning induces robust neuroprotection against stroke by a novel type I interferon-mediated mechanism

BACKGROUND AND PURPOSE: Systemic administration of Toll-like receptor 4 (TLR4) and TLR9 agonists prior to cerebral ischemia, have been shown to reduce ischemic injury by reprogramming the brain’s response to stroke. Our goal was to explore the mechanism of TLR induced neuroprotection by determining...

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Autors principals: Leung, Philberta Y., Stevens, Susan L., Packard, Amy E.B., Lessov, Nikola S., Yang, Tao, Conrad, Valerie K., van den Dungen, Noortje N.A.M., Simon, Roger P., Stenzel-Poore, Mary P.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943206/
https://ncbi.nlm.nih.gov/pubmed/22403050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.111.641522
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