LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury

BACKGROUND: Toll-like receptor 4 (TLR4) is activated in response to cerebral ischemia leading to substantial brain damage. In contrast, mild activation of TLR4 by preconditioning with low dose exposure to lipopolysaccharide (LPS) prior to cerebral ischemia dramatically improves outcome by reprogramm...

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Bibliografiske detaljer
Main Authors: Vartanian, Keri B, Stevens, Susan L, Marsh, Brenda J, Williams-Karnesky, Rebecca, Lessov, Nikola S, Stenzel-Poore, Mary P
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217906/
https://ncbi.nlm.nih.gov/pubmed/21999375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-140
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