TLR7 preconditioning induces robust neuroprotection against stroke by a novel type I interferon-mediated mechanism

BACKGROUND AND PURPOSE: Systemic administration of Toll-like receptor 4 (TLR4) and TLR9 agonists prior to cerebral ischemia, have been shown to reduce ischemic injury by reprogramming the brain’s response to stroke. Our goal was to explore the mechanism of TLR induced neuroprotection by determining...

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Bibliographische Detailangaben
Hauptverfasser: Leung, Philberta Y., Stevens, Susan L., Packard, Amy E.B., Lessov, Nikola S., Yang, Tao, Conrad, Valerie K., van den Dungen, Noortje N.A.M., Simon, Roger P., Stenzel-Poore, Mary P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943206/
https://ncbi.nlm.nih.gov/pubmed/22403050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.111.641522
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