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Cullin-based ubiquitin ligases: Cul3–BTB complexes join the family
Cullin-based E3 ligases target substrates for ubiquitin-dependent degradation by the 26S proteasome. The SCF (Skp1–Cul1–F-box) and ECS (ElonginC–Cul2–SOCS box) complexes are so far the best-characterized cullin-based ligases. Their atomic structure has been solved recently, and several substrates ha...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC394240/ https://ncbi.nlm.nih.gov/pubmed/15071497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600186 |
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