The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K(+)–Cl(−) co-transporters

Precise homoeostasis of the intracellular concentration of Cl(−) is achieved via the co-ordinated activities of the Cl(−) influx and efflux. We demonstrate that the WNK (WNK lysine-deficient protein kinase)-activated SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive k...

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Autores principales: delos Heros, Paola, Alessi, Dario R., Gourlay, Robert, Campbell, David G., Deak, Maria, Macartney, Thomas J., Kahle, Kristopher T., Zhang, Jinwei
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940040/
https://ncbi.nlm.nih.gov/pubmed/24393035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20131478
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