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G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding
Human telomeres terminate with a single-stranded 3′ G overhang, which can be recognized as a DNA damage site by replication protein A (RPA). The protection of telomeres (POT1)/POT1-interacting protein 1 (TPP1) heterodimer binds specifically to single-stranded telomeric DNA (ssTEL) and protects G ove...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3939921/ https://ncbi.nlm.nih.gov/pubmed/24516170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321436111 |
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