G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding

Human telomeres terminate with a single-stranded 3′ G overhang, which can be recognized as a DNA damage site by replication protein A (RPA). The protection of telomeres (POT1)/POT1-interacting protein 1 (TPP1) heterodimer binds specifically to single-stranded telomeric DNA (ssTEL) and protects G ove...

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Bibliographic Details
Main Authors: Ray, Sujay, Bandaria, Jigar N., Qureshi, Mohammad H., Yildiz, Ahmet, Balci, Hamza
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939921/
https://ncbi.nlm.nih.gov/pubmed/24516170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321436111
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