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Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging

The mitochondrial theory of aging is widely popular but confronted by several apparent inconsistencies. On the one hand, mitochondrial energy production is of central importance to the health and proper functioning of cells, and single-cell studies have shown that mtDNA deletion mutants accumulate i...

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Autors principals: Kowald, Axel, Kirkwood, Thomas B. L.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939916/
https://ncbi.nlm.nih.gov/pubmed/24569805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314970111
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