JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation

Extracellular high-mobility group box (HMGB)1 mediates inflammation during sterile and infectious injury and contributes importantly to disease pathogenesis. The first critical step in the release of HMGB1 from activated immune cells is mobilization from the nucleus to the cytoplasm, a process depen...

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Dades bibliogràfiques
Autors principals: Lu, Ben, Antoine, Daniel J., Kwan, Kevin, Lundbäck, Peter, Wähämaa, Heidi, Schierbeck, Hanna, Robinson, Melissa, Van Zoelen, Marieke A. D., Yang, Huan, Li, Jianhua, Erlandsson-Harris, Helena, Chavan, Sangeeta S., Wang, Haichao, Andersson, Ulf, Tracey, Kevin J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939889/
https://ncbi.nlm.nih.gov/pubmed/24469805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1316925111
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