ELF4 is critical for induction of type I interferon and the host antiviral response

Induction of type I interferon is a central event of innate immunity, essential for host defense. Here we report that the transcription factor ELF4 is induced by type I interferon and upregulates interferon expression in a feed-forward loop. ELF4 deficiency leads to reduced interferon production, re...

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Autori principali: You, Fuping, Wang, Penghua, Yang, Long, Yang, Guang, Zhao, Yang O, Qian, Feng, Walker, Wendy, Sutton, Richard, Montgomery, Ruth, Lin, Rongtuan, Iwasaki, Akiko, Fikrig, Erol
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939855/
https://ncbi.nlm.nih.gov/pubmed/24185615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2756
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