HIPK2 is necessary for type I interferon–mediated antiviral immunity

Precise control of interferons (IFNs) is crucial to maintain immune homeostasis. Here, we demonstrated that homeodomain-interacting protein kinase 2 (HIPK2) was required for the production of type I IFNs in response to RNA virus infection. HIPK2 deficiency markedly impaired IFN production in macroph...

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Udgivet i:Sci Signal
Main Authors: Cao, Lili, Yang, Guang, Gao, Shandian, Jing, Chunxia, Montgomery, Ruth R., Yin, Yuxin, Wang, Penghua, Fikrig, Erol, You, Fuping
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893850/
https://ncbi.nlm.nih.gov/pubmed/30890658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau4604
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