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Buffer-dependent fragmentation of a humanized full-length monoclonal antibody
During storage stability studies of a monoclonal antibody (mAb) it was determined that the primary route of degradation involved fragmentation into lower molecular weight species. The fragmentation was characterized with size-exclusion high performance liquid chromatography (SE-HPLC), SDS-PAGE and m...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3938388/ https://ncbi.nlm.nih.gov/pubmed/20091831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.22056 |
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