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Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation
Opalescence and high viscosities can pose challenges for high concentration formulation of antibodies. Both phenomena result from protein-protein intermolecular interactions that can be modulated with solution ionic strength. We studied a therapeutic monoclonal antibody that exhibits high viscosity...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3927449/ https://ncbi.nlm.nih.gov/pubmed/19475558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21797 |
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