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Response of a Concentrated Monoclonal Antibody Formulation to High Shear
There is concern that shear could cause protein unfolding or aggregation during commercial biopharmaceutical production. In this work we exposed two concentrated immunoglobulin-G1 (IgG1) monoclonal antibody (mAb, at >100 mg/mL) formulations to shear rates of between 20,000 and 250,000 s(-1) for b...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2724069/ https://ncbi.nlm.nih.gov/pubmed/19370772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.22336 |
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