Monoclonal Antibody Interactions with Micro- and Nanoparticles: Adsorption, Aggregation and Accelerated Stress Studies

Therapeutic proteins are exposed to various wetted surfaces that could shed sub-visible particles. In this work we measured the adsorption of a monoclonal antibody (mAb) to various microparticles, characterized the adsorbed mAb secondary structure, and determined the reversibility of adsorption. We...

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Bibliografiske detaljer
Main Authors: Bee, Jared S., Chiu, David, Sawicki, Suzanne, Stevenson, Jennifer L., Chatterjee, Koustuv, Freund, Erwin, Carpenter, John F., Randolph, Theodore W.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749556/
https://ncbi.nlm.nih.gov/pubmed/19492408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21768
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