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Particle Formation and Aggregation of a Therapeutic Protein in Nanobubble Suspensions

The generation of nanobubbles following reconstitution of lyophilized trehalose formulations has recently been reported.(1) Here, we characterize particle formation and aggregation of recombinant human interleukin-1 receptor antagonist (rhIL-1ra) in reconstituted formulations of lyophilized trehalos...

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Detalhes bibliográficos
Publicado no:J Pharm Sci
Main Authors: Snell, Jared R., Zhou, Chen, Carpenter, John F., Randolph, Theodore W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021584/
https://ncbi.nlm.nih.gov/pubmed/27488901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.06.020
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