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Nanobubbles in Reconstituted Lyophilized Formulations: Interaction with Proteins and Mechanism of Formation

Reconstitution of lyophilized disaccharide formulations results in the formation of nano-sized air bubbles that persist in suspension for weeks. If proteins are present, interactions with nanobubbles may cause loss of monomeric protein and formation of sub-visible particles. The goals of this work a...

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Pubblicato in:J Pharm Sci
Autori principali: Snell, Jared R., Krishna Kumar, N. S., Suryanarayanan, Raj, Randolph, Theodore W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851470/
https://ncbi.nlm.nih.gov/pubmed/31095959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2019.05.005
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