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Nanobubbles in Reconstituted Lyophilized Formulations: Interaction with Proteins and Mechanism of Formation
Reconstitution of lyophilized disaccharide formulations results in the formation of nano-sized air bubbles that persist in suspension for weeks. If proteins are present, interactions with nanobubbles may cause loss of monomeric protein and formation of sub-visible particles. The goals of this work a...
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| Опубликовано в: : | J Pharm Sci |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6851470/ https://ncbi.nlm.nih.gov/pubmed/31095959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2019.05.005 |
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