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Storage Stability of Keratinocyte Growth Factor-2 in Lyophilized Formulations: Effects of Formulation Physical Properties and Protein Fraction at the Solid-Air Interface

Lyophilized formulations of keratinocyte growth factor-2 (KGF-2) were prepared with a range of disaccharide (sucrose or trehalose) and hydroxyethyl starch (HES) mass ratios. Protein degradation was assessed as a function of time of storage of the dried formulations at 40, 50 and 60 °C. Lyophilized a...

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Detalhes bibliográficos
Publicado no:Eur J Pharm Biopharm
Main Authors: Devineni, Dilip, Gonschorek, Christoph, Cicerone, Marcus T, Xu, Yemin, Carpenter, John F., Randolph, Theodore W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240752/
https://ncbi.nlm.nih.gov/pubmed/24859390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejpb.2014.05.012
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