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Storage Stability of Keratinocyte Growth Factor-2 in Lyophilized Formulations: Effects of Formulation Physical Properties and Protein Fraction at the Solid-Air Interface
Lyophilized formulations of keratinocyte growth factor-2 (KGF-2) were prepared with a range of disaccharide (sucrose or trehalose) and hydroxyethyl starch (HES) mass ratios. Protein degradation was assessed as a function of time of storage of the dried formulations at 40, 50 and 60 °C. Lyophilized a...
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| Vydáno v: | Eur J Pharm Biopharm |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4240752/ https://ncbi.nlm.nih.gov/pubmed/24859390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejpb.2014.05.012 |
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