Sirt2 Deacetylase Is a Novel AKT Binding Partner Critical for AKT Activation by Insulin

AKT/PKB kinases transmit insulin and growth factor signals downstream of phosphatidylinositol 3-kinase (PI3K). AKT activation involves phosphorylation at two residues, Thr(308) and Ser(473), mediated by PDK1 and the mammalian target of rapamycin complex 2 (mTORC2), respectively. Impaired AKT activat...

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Bibliographische Detailangaben
Hauptverfasser: Ramakrishnan, Gopalakrishnan, Davaakhuu, Gantulga, Kaplun, Ludmila, Chung, Wen-Cheng, Rana, Ajay, Atfi, Azeddine, Miele, Lucio, Tzivion, Guri
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937672/
https://ncbi.nlm.nih.gov/pubmed/24446434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.537266
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