HIV-1 Vif N-terminal Motif is required for recruitment of Cul5 to Suppress APOBEC3

BACKGROUND: HIV-1 Vif promotes the degradation of host anti-retroviral factor family, APOBEC3 proteins via the recruitment of a multi-subunit E3 ubiquitin ligase complex. The complex is composed of a scaffold protein, Cullin 5 (Cul5), RING-box protein (Rbx), a SOCS box binding protein complex, Elong...

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Autori principali: Evans, Sean L, Schön, Arne, Gao, Qimeng, Han, Xue, Zhou, Xiaohong, Freire, Ernesto, Yu, Xiao-Fang
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937519/
https://ncbi.nlm.nih.gov/pubmed/24422669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-11-4
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