DNA polymerase preference determines PCR priming efficiency

BACKGROUND: Polymerase chain reaction (PCR) is one of the most important developments in modern biotechnology. However, PCR is known to introduce biases, especially during multiplex reactions. Recent studies have implicated the DNA polymerase as the primary source of bias, particularly initiation of...

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Bibliographic Details
Main Authors: Pan, Wenjing, Byrne-Steele, Miranda, Wang, Chunlin, Lu, Stanley, Clemmons, Scott, Zahorchak, Robert J, Han, Jian
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937175/
https://ncbi.nlm.nih.gov/pubmed/24479830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-14-10
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