Acetylation of RNA Polymerase II Regulates Growth-Factor-Induced Gene Transcription in Mammalian Cells

Lysine acetylation regulates transcription by targeting histones and nonhistone proteins. Here we report that the central regulator of transcription, RNA polymerase II, is subject to acetylation in mammalian cells. Acetylation occurs at eight lysines within the C-terminal domain (CTD) of the largest...

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Main Authors: Schröder, Sebastian, Herker, Eva, Itzen, Friederike, He, Daniel, Thomas, Sean, Gilchrist, Daniel A., Kaehlcke, Katrin, Cho, Sungyoo, Pollard, Katherine S., Capra, John A., Schnölzer, Martina, Cole, Philip A., Geyer, Matthias, Bruneau, Benoit G., Adelman, Karen, Ott, Melanie
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936344/
https://ncbi.nlm.nih.gov/pubmed/24207025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.10.009
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