Two-pronged Binding with Bromodomain-containing Protein 4 Liberates Positive Transcription Elongation Factor b from Inactive Ribonucleoprotein Complexes

The positive transcription elongation factor b (P-TEFb) exists in two forms in cells as follows: an inactive form where the core components cyclin T1 and CDK9 are incorporated in the 7SK small nuclear ribonucleoprotein complex containing the inhibitory molecule HEXIM1, and an active form, part of wh...

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Detalhes bibliográficos
Main Authors: Schröder, Sebastian, Cho, Sungyoo, Zeng, Lei, Zhang, Qiang, Kaehlcke, Katrin, Mak, Lily, Lau, Joann, Bisgrove, Dwayne, Schnölzer, Martina, Verdin, Eric, Zhou, Ming-Ming, Ott, Melanie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256921/
https://ncbi.nlm.nih.gov/pubmed/22084242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.282855
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