Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells

The elongation competence of the RNA polymerase II complex is critically dependent on the positive transcription elongation factor b (P-TEFb). P-TEFb exists in two forms in cells, an active form composed of cyclin T1 and CDK9 and an inactive form, in which cyclin T1/CDK9 is sequestered by Hexim1 and...

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Main Authors: Cho, Sungyoo, Schroeder, Sebastian, Kaehlcke, Katrin, Kwon, Hye-Sook, Pedal, Angelika, Herker, Eva, Schnoelzer, Martina, Ott, Melanie
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688543/
https://ncbi.nlm.nih.gov/pubmed/19387490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.99
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