Ectopic TLX1 Expression Accelerates Malignancies in Mice Deficient in DNA-PK

The noncluster homeobox gene HOX11/TLX1 (TLX1) is detected at the breakpoint of the t(10;14)(q24;q11) chromosome translocation in patients with T cell acute lymphoblastic leukemia (T-ALL). This translocation results in the inappropriate expression of TLX1 in T cells. The oncogenic potential of TLX1...

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Detalhes bibliográficos
Main Authors: Krutikov, Konstantin, Zheng, Yanzhen, Chesney, Alden, Huang, Xiaoyong, Vaags, Andrea K., Evdokimova, Valentina, Hough, Margaret R., Chen, Edwin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935916/
https://ncbi.nlm.nih.gov/pubmed/24586935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089649
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