The Progeroid Phenotype of Ku80 Deficiency Is Dominant over DNA-PK(CS) Deficiency

Ku80 and DNA-PK(CS) are both involved in the repair of double strand DNA breaks via the nonhomologous end joining (NHEJ) pathway. While ku80(−/−) mice exhibit a severely reduced lifespan and size, this phenotype is less pronounced in dna-pk(cs)(−/−) mice. However, these observations are based on ind...

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Main Authors: Reiling, Erwin, Dollé, Martijn E. T., Youssef, Sameh A., Lee, Moonsook, Nagarajah, Bhawani, Roodbergen, Marianne, de With, Piet, de Bruin, Alain, Hoeijmakers, Jan H., Vijg, Jan, van Steeg, Harry, Hasty, Paul
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989187/
https://ncbi.nlm.nih.gov/pubmed/24740260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093568
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