Broad segmental progeroid changes in short-lived Ercc1(−/Δ7) mice

Genome maintenance is considered a prime longevity assurance mechanism as apparent from many progeroid human syndromes that are caused by genome maintenance defects. The ERCC1 protein is involved in three genome maintenance systems: nucleotide excision repair, interstrand cross-link repair, and homo...

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Main Authors: Dollé, Martijn E.T., Kuiper, Raoul V., Roodbergen, Marianne, Robinson, Joke, de Vlugt, Sisca, Wijnhoven, Susan W.P., Beems, Rudolf B., de la Fonteyne, Liset, de With, Piet, van der Pluijm, Ingrid, Niedernhofer, Laura J., Hasty, Paul, Vijg, Jan, Hoeijmakers, Jan H.J., van Steeg, Harry
Format: Artigo
Sprog:Inglês
Udgivet: Co-Action Publishing 2011
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417667/
https://ncbi.nlm.nih.gov/pubmed/22953029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3402/pba.v1i0.7219
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