An Xpb Mouse Model for Combined Xeroderma Pigmentosum and Cockayne Syndrome Reveals Progeroid Features upon Further Attenuation of DNA Repair

Patients carrying mutations in the XPB helicase subunit of the basal transcription and nucleotide excision repair (NER) factor TFIIH display the combined cancer and developmental-progeroid disorder xeroderma pigmentosum/Cockayne syndrome (XPCS). Due to the dual transcription repair role of XPB and t...

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Hauptverfasser: Andressoo, Jaan-Olle, Weeda, Geert, de Wit, Jan, Mitchell, James R., Beems, Rudolf B., van Steeg, Harry, van der Horst, Gijsbertus T. J., Hoeijmakers, Jan H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643825/
https://ncbi.nlm.nih.gov/pubmed/19114557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01229-08
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