An Xpb Mouse Model for Combined Xeroderma Pigmentosum and Cockayne Syndrome Reveals Progeroid Features upon Further Attenuation of DNA Repair

Patients carrying mutations in the XPB helicase subunit of the basal transcription and nucleotide excision repair (NER) factor TFIIH display the combined cancer and developmental-progeroid disorder xeroderma pigmentosum/Cockayne syndrome (XPCS). Due to the dual transcription repair role of XPB and t...

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Autors principals: Andressoo, Jaan-Olle, Weeda, Geert, de Wit, Jan, Mitchell, James R., Beems, Rudolf B., van Steeg, Harry, van der Horst, Gijsbertus T. J., Hoeijmakers, Jan H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643825/
https://ncbi.nlm.nih.gov/pubmed/19114557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01229-08
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