High Preservation of CpG Cytosine Methylation Patterns at Imprinted Gene Loci in Liver and Brain of Aged Mice

A gradual loss of the correct patterning of 5-methyl cytosine marks in gene promoter regions has been implicated in aging and age-related diseases, most notably cancer. While a number of studies have examined DNA methylation in aging, there is no consensus on the magnitude of the effects, particular...

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Hlavní autoři: Gravina, Silvia, Dollé, Martijn E. T., Wang, Tao, van Steeg, Harry, Hasty, Paul, Hoeijmakers, Jan, Vijg, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767788/
https://ncbi.nlm.nih.gov/pubmed/24039963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073496
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