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New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases
E3 ubiquitin ligases that direct substrate proteins to the ubiquitin–proteasome system are promising, though largely unexplored drug targets both because of their function and their remarkable specificity. CRLs [Cullin–RING (really interesting new gene) ligases] are the largest group of E3 ligases a...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Portland Press Ltd.
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3935762/ https://ncbi.nlm.nih.gov/pubmed/24450635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20130215 |
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