β-Arrestin-1 Drives Endothelin-1–Mediated Podocyte Activation and Sustains Renal Injury

Activation of endothelin-A receptor (ET(A)R) by endothelin-1 (ET-1) drives epithelial-to-mesenchymal transition in ovarian tumor cells through β-arrestin signaling. Here, we investigated whether this pathogenetic pathway could affect podocyte phenotype in proliferative glomerular disorders. In cultu...

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Hlavní autoři: Buelli, Simona, Rosanò, Laura, Gagliardini, Elena, Corna, Daniela, Longaretti, Lorena, Pezzotta, Anna, Perico, Luca, Conti, Sara, Rizzo, Paola, Novelli, Rubina, Morigi, Marina, Zoja, Carlamaria, Remuzzi, Giuseppe, Bagnato, Anna, Benigni, Ariela
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2014
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935587/
https://ncbi.nlm.nih.gov/pubmed/24371298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013040362
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