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Activated PLC-γ1 is Catalytically Induced at LAT but Activated PLC-γ1 is Localized at both LAT- and TCR-Containing Complexes

Phospholipase C-γ1 (PLC-γ1) is a key regulator of T cell receptor (TCR)-induced signaling. Activation of the TCR enhances PLC-γ1 enzymatic function, resulting in calcium influx and the activation of PKC family members and RasGRP. The current model is that phosphorylation of LAT tyrosine 132 facilita...

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Bibliografiska uppgifter
Huvudupphovsmän: Cruz-Orcutt, Noemi, Vacaflores, Aldo, Connolly, Sean F., Bunnell, Stephen C., Houtman, Jon C.D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935424/
https://ncbi.nlm.nih.gov/pubmed/24412752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2013.12.022
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